4.4 Article

Three component coupling catalyzed by TaCl5-SiO2:: synthesis of α-amino phosphonates

Journal

TETRAHEDRON LETTERS
Volume 42, Issue 32, Pages 5561-5563

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(01)01053-X

Keywords

carbonyl compound; amine; diethyl phosphite; alpha-amino phosphonate; TaCl5

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TaCl5-SiO2 has been utilized as an efficient Lewis acid catalyst for the three component coupling of carbonyl compounds, aromatic amines and diethyl phosphite to produce a-amino phosphonates. (C) 2001 Published by Elsevier Science Ltd.

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