Journal
CURRENT BIOLOGY
Volume 11, Issue 15, Pages R592-R595Publisher
CELL PRESS
DOI: 10.1016/S0960-9822(01)00360-8
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Dickkopf proteins are secreted antagonists of the Wnt cell signalling molecules, which have a novel mode of action. Dickkopf1 binds to the LRP5/6 Wnt co-receptor and prevents the formation of active Wnt-Frizzled-LRP5/6 receptor complexes, thus blocking the canonical Wnt-beta -catenin pathway.
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