Journal
FEMS MICROBIOLOGY LETTERS
Volume 202, Issue 1, Pages 139-143Publisher
ELSEVIER SCIENCE BV
DOI: 10.1111/j.1574-6968.2001.tb10794.x
Keywords
mex multidrug efflux pump; a series of deletion mutants; drug specificity; MexCD-OprM; Pseudomonas aeruginosa
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We constructed a series of deletion mutants lacking all of the four major mex operons for Mex multidrug efflux pumps or possessing each one of the operons from Pseudomonas aeruginosa PAO1. The drug specificity of MexAB-OprM, MexXY-OprM and MexCD-OprJ was investigated. Surprisingly, we found that the MexCD-OprJ was an inducible pump, inducers of which were tetraphenylphosphonium chloride, ethidium bromide, rhodamine 6G and acriflavine. Fluoroquinolones, chloramphenicol, erythromycin and tetracycline were not inducers although they were substrates of MexCD-OprJ. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
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