Journal
NEUROSCIENCE LETTERS
Volume 308, Issue 3, Pages 145-148Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(01)02020-1
Keywords
prefrontal cortex; memory; medial precentral; response learning; anterior cingulate; motor learning
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Funding
- NIMH NIH HHS [MH11741] Funding Source: Medline
- NINDS NIH HHS [NS20771] Funding Source: Medline
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The present experiment studied the effects of quinolinic acid (90 mM) lesions of the medial precentral and anterior cingulate on working memory for egocentric responses. Rats were trained on a delayed match-to-sample task that involved memory for a 90 degrees right or left turn. The results indicated that lesioned rats had significantly decreased scores during the 10 s delay condition compared to presurgery levels. An increase in the delay to 20 s significantly reduced working memory performance in the lesioned rats compared to that of controls. These findings suggest that the rat medial precentral and/or anterior cingulate area play an important role in working memory for egocentric responses. (C) 2001 Published by Elsevier Science Ireland Ltd.
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