Journal
SCIENCE
Volume 293, Issue 5532, Pages 1164-1166Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1060937
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The power of placebos has long been recognized for improving numerous medical conditions such as Parkinson's disease (PID). Little is known, however, about the mechanism underlying the placebo effect. Using the ability of endogenous dopamine to compete for [C-11]raclopride binding as measured by positron emission tomography, we provide in vivo evidence for substantial release of endogenous dopamine in the striatum of PID, patients in response to placebo. Our findings indicate that the placebo effect in PID is powerful and is mediated through activation of the damaged nigrostriatal dopamine system.
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