Journal
CELL
Volume 106, Issue 3, Pages 355-366Publisher
CELL PRESS
DOI: 10.1016/S0092-8674(01)00444-5
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Funding
- NCI NIH HHS [CA 23928] Funding Source: Medline
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Frizzled (Fz) signaling regulates cell polarity in both vertebrates and invertebrates. In Drosophila, Fz orients the asymmetric division of the sensory organ precursor cell (pl) along the antero-posterior axis of the notum. Planar polarization involves a remodeling of the apical-basal polarity of the pi cell. The Discs-large (Dlg) and Partner of Inscuteable (Pins) proteins accumulate at the anterior cortex, while Bazooka (Baz) relocalizes to the posterior cortex. Dig interacts directly with Pins and regulates the localization of Pins and Baz. Pins acts with Fz to localize Baz posteriorly, but Baz is not required to localize Pins anteriorly. Finally, Baz and the Dig/Pins complex are required for the asymmetric localization of Numb. Thus, the Dig/Pins complex responds to Fz signaling to establish planar asymmetry in the pl cell.
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