Synthesis and stereochemical confirmation of the HI/JK ring system of prymnesins, potent hemolytic and ichthyotoxic glycoside toxins isolated from the red tide alga

Stereocontrolled synthesis of the HI/JK ring model of the prymnesins, glyosidic toxins isolated from the red tide phytoflagellate Prymnesium parvum, is described. Comparison of its H-1 and C-13 NMR data with those of the natural toxins established the earlier stereochemical assignments. (C) 2001 Elsevier Science Ltd. All rights reserved.