Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 224, Issue 1-2, Pages 19-38Publisher
ELSEVIER
DOI: 10.1016/S0378-5173(01)00720-7
Keywords
colon-specific drug delivery; colon targeting; polysaccharides; oligosaccharide
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Natural polysaccharides are now extensively used for the development of solid dosage forms for delivery of drug to the colon. The rationale for the development of a polysaccharide based delivery system for colon is the presence of large amounts of polysaccharidases in the human colon as the colon is inhabited by a large number and variety of bacteria which secrete many enzymes e.g. beta -D-glucosidase, beta -D-galactosidase, amylase, pectinase. xylanase, beta -D-xylosidase, dextranase, etc. Various major approaches utilizing polysaccharides for colon-specific delivery are fermentable coating of the drug core, embedding of the drug in biodegradable matrix, formulation of drug-saccharide conjugate (prodrugs). A large number of polysaccharides have already been studied for their potential as colon-specific drug carrier systems, such as chitosan, pectin, chondroitin sulphate, cyclodextrin, dextrans, guar gum, inulin, amylose and locust bean gum. Recent efforts and approaches exploiting these polysaccharides in colon-specific drug delivery are discussed. (C) 2001 Elsevier Science B.V. All rights reserved.
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