Journal
HUMAN MOLECULAR GENETICS
Volume 10, Issue 17, Pages 1847-1851Publisher
OXFORD UNIV PRESS
DOI: 10.1093/hmg/10.17.1847
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Funding
- NIEHS NIH HHS [ES10751] Funding Source: Medline
- NINDS NIH HHS [NS33978] Funding Source: Medline
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We report haplotype analysis of the alpha -synuclein gene in Parkinson's disease (PD), extending earlier reports of an association with a polymorphism within the gene promoter. This analysis showed significant differences in haplotypes between PD cases and controls. Our analyses demonstrate that genetic variability in the alpha -synuclein gene is a risk factor for the development of PD. These genetic findings are analogous to the tau haplotype over-represented in progressive supranuclear palsy and further extend the similarity in the etiologies and pathogeneses of the synucleinopathies and tauopathies.
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