Journal
BIOLOGICAL PSYCHIATRY
Volume 50, Issue 4, Pages 305-309Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0006-3223(01)01105-2
Keywords
child maltreatment; amygdala; hippocampus; neurodevelopment; posttraumatic stress disorder
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Background: Adult posttraumatic stress disorder (PTSD) is associated with decreased hippocampal volumes; however, decreased hippocampal volumes were not seen in pediatric maltreatment-related PTSD. We examined hippocampal volumes longitudinally to determine if a history of childhood traumatic stress alters hippocampal growth during puberty. Methods: Magnetic resonance imaging was used to measure temporal lobes, amygdala, and hippocampal volumes in nine prepubertal maltreated subjects with pediatric maltreatment-related PTSD and nine sociodemographically matched healthy nonmaltreated yoked control subjects at baseline and after at least 2 years follow-up (during the later stages of pubertal development) using identical equipment and measurement methodology. Results: Temporal lobe, amygdala and hippocampal volumes did not differ between groups at baseline, follow-up, or across time. Conclusions: Whereas these data are from a small sample, the results do not support hippocampal changes in pediatric maltreatment-related PTSD. (C) 2001 Society of Biological Psychiatry.
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