Journal
JOURNAL OF IMMUNOLOGY
Volume 167, Issue 4, Pages 2361-2369Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.167.4.2361
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Funding
- NIAID NIH HHS [NIAID-DAIT-99-12, 1-R29-AI42862-01] Funding Source: Medline
- NIAMS NIH HHS [R01-AR46589-01] Funding Source: Medline
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We have analyzed the blood B cell subpopulations of children with systemic lupus erythematosus (SLE) and healthy controls. We found that the normal recirculating mature B cell pool is composed of four subsets: conventional naive and memory B cells, a novel B cell subset with pregerminal center phenotype (IgD(+)CD38(+)centerin(+)), and a plasma cell precursor subset (CD20(-)CD19(+/low)CD27(+/++) CD38(++)). In SLE patients, naive and memory B cells (CD20(+)CD38(-)) are similar to 90% reduced, whereas oligoclonal plasma cell precursors are 3-fold expanded, independently of disease activity and modality of therapy. Pregerminal center cells in SLE are decreased to a lesser extent than conventional B cells, and therefore represent the predominant blood B cell subset in a number of patients. Thus, SLE is associated with major blood B cell subset alterations.
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