Journal
JOURNAL OF IMMUNOLOGY
Volume 167, Issue 4, Pages 1929-1934Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.167.4.1929
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IL-7 and IL-15 play important roles in gamma delta T cell development. These receptors transmit proliferation and/or survival signals in,gamma delta T cells. In addition, the IL-7R promotes recombination and transcription in the TCR gamma locus. To clarify the role of the cytokine receptors in the development of epidermal gamma delta T cells, we introduced a V gamma3/V delta1 TCR transgene, derived from Thy-1(+) dendritic epidermal T cells (DETC), into IL-7R alpha -deficient mice, and we found that they partly rescued gamma delta T cells in the adult thymus but not in the spleen. Introduction of an additional Bcl-2 transgene had a minimal effect on gamma delta T cells in the adult thymus of these mice. In contrast to the adult thymus, the introduction of the V gamma3/V delta1 TCR transgene into IL-7R alpha (-/-) mice completely restored V gamma3(+) T cells in the fetal thymus and DETC in the adult skin. On the contrary, the same V gamma3/V delta1 TCR transgene failed to rescue DETC in the skin of IL-2R beta -deficient mice, even with the additional Bcl-2 transgene. These results suggest that the IL-2/IL-15R, rather than the IL-7R, plays an essential role in proliferation and survival of DETC in the fetal thymus and the skin. In contrast, the IL-7R is probably essential in the induction of V-J recombination of TCR gamma genes. Thus, this study proves that IL-7R and IL-2/IL-15R serve differential functions in epidermal gamma delta T cell development.
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