Journal
GENE
Volume 274, Issue 1-2, Pages 1-13Publisher
ELSEVIER
DOI: 10.1016/S0378-1119(01)00625-4
Keywords
transcription; signaling; growth factors; kinase; nuclear translocation
Categories
Funding
- NIAID NIH HHS [AI 45150] Funding Source: Medline
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An animal cell has the capability to respond to a variety of external signals through cell surface receptors. The response is usually manifested in terms of altered gene expression in the nucleus. Thus, in modem molecular and cell biology, it has become important to understand how the communication between extracellular signals and nuclear gene transcription is achieved. Originally discovered as a basal factor required for initiator-dependent transcription in vitro, recent evidence suggests that TFII-I is also an inducible multifunctional transcription factor that is activated in response to a variety of extracellular signals and translocates to the nucleus to turn on signal-induced genes. Here I review the biochemical and biological properties of TFJI-I and related proteins in nuclear gene transcription, signal transduction and genetic disorders. (C) 2001 Elsevier Science B.V. All rights reserved.
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