Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 927, Issue 1-2, Pages 47-52Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0021-9673(01)01060-3
Keywords
enantiomer separation; mobile phase composition; phenylalanine analogues; acidic additives
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The use of acidic mobile phase additives allows the chiral separation of underivatized phenylalanine analogs on a common amylosic column. In addition to decreasing retention and band-broadening arising from non-ideal interactions, acidic additives may also increase selectivity. This appears to be due to the minimization of non-selective binding in the recognition site. Effects of the additives are related to additive pK(a) and size. Ethanesulfonic acid was typically the most effective additive with trifluoroacetic acid being one of the least effective. (C) DuPont Pharmaceutical Company. Published by Elsevier Science B.V. All rights reserved.
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