Journal
SCIENCE
Volume 293, Issue 5534, Pages 1503-1506Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1061548
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The quiescent nature of most peripheral T cells poses an effective limitation to human immunodeficiency virus (HIV) replication and, in particular, to viral integration into the host chromatin. Two HIV proteins, Nef and Tat, increase T cell activity, but a requirement of integration for viral gene expression would preclude a rote for these proteins in resting cells. Here, we report that HIV infection leads to selective transcription of the nef and tat genes before integration. This preintegration transcription in quiescent cells leads to increased T cell activation and viral replication.
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