Journal
CELL
Volume 106, Issue 4, Pages 511-521Publisher
CELL PRESS
DOI: 10.1016/S0092-8674(01)00465-2
Keywords
-
Categories
Funding
- NICHD NIH HHS [HD27056] Funding Source: Medline
Ask authors/readers for more resources
Neural precursors often generate distinct cell types in a specific order, but the intrinsic or extrinsic cues regulating the timing of cell fate specification are poorly understood. Here we show that Drosophila neural precursors (neuroblasts) sequentially express the transcription factors Hunchback --> Kruppel --> Pdm --> Castor, with differentiated progeny maintaining the transcription factor profile present at their birth. Hunchback is necessary and sufficient for first-born cell fates, whereas Kruppel is necessary and sufficient for second-born cell fates; this is observed in multiple lineages and is independent of the cell type involved. We propose that Hunchback and Kruppel control early-born temporal identity in neuroblast cell lineages.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available