Journal
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
Volume 30, Issue 1, Pages 37-44Publisher
WILEY
DOI: 10.1002/jbt.21740
Keywords
Thymol; Carvacrol; Anti-Oxidant; Doxorubicin; Cardiotoxicity
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The aim of this study was to assess the possible protective effects of thymol and carvacrol (CAR) against doxorubicin (DOX)-induced cardiotoxicity. A single dose of DOX (10 mg/kg i.v.) injected to male rats revealed significant increases in serum lactate dehydrogenase, creatine kinase, creatine kinase isoenzyme-MB, aspartate transaminase, tumor necrosis factor-alpha, and cardiac troponin levels. It also increased heart contents of malondialdehyde and caspase-3 accompanied by a significant reduction in heart content of reduced glutathione as well as catalase and superoxide dismutase activity as compared with the control group. In contrast, administration of thymol (20 mg/kg p.o.) and/or CAR (25 mg/kg p.o.) for 14 days before DOX administration and for 2 days after DOX injection ameliorated the heart function and oxidative stress parameters. Summarily, thymol was more cardioprotective than CAR. Moreover, a combination of thymol and CAR had a synergistic cardioprotective effect that might be attributed to antioxidant, anti-inflammatory, and antiapoptotic activities.
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