A novel route to 2-(dialkylaminomethyl)benzo[b]furans via a microwave-enhanced, solventless Mannich condensation-cyclization on cuprous iodide doped alumina

A microwave-enhanced, solventless Mannich condensation-cyclization Sequence involving the reaction of o-ethynylphenol with secondary amines and para-formaldehyde on cuprous iodide doped alumina it) the absence of solvents has been developed. The procedure generates 2-(dialkylaminomethyl)benzo[b]furans in good yields. (C) 2001 Elsevier Science Ltd. All rights reserved.