Journal
NEUROLOGY
Volume 57, Issue 4, Pages 731-733Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.57.4.731
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The authors evaluated whether glatiramer acetate (GA) modifies the severity of tissue damage in 1,722 new lesions from 239 patients with MS enrolled in a placebo-controlled trial monitored with monthly cerebral MRI. The percentage of new lesions that evolved into black holes was lower in GA-treated than in placebo patients on scans at 7 (18.9 and 26.3%; p = 0.04) and 8 (15.6 and 31.4%; p = 0.002) months after lesion appearance. GA has a favorable effect on tissue disruption in MS lesions once they are formed.
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