Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 311, Issue 5, Pages 1081-1090Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1006/jmbi.2001.4900
Keywords
de novo protein design; coiled coil; alpha-helical barrel; To1C; cytochrome bc(1); domain-swapped dimer
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Funding
- NIGMS NIH HHS [GM56423, GM54616] Funding Source: Medline
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Antiparallel helical bundles are found in a wide range of proteins. Often, four-helical bundles form tube-like structures, with binding sites for substrates or cofactors near their centers. For example, a transmembrane four-helical bundle in cytochrome bc(1) binds a pair of porphyrins in an elongated central cavity running down the center of the structure. Antiparallel helical barrels with larger diameters are found in the crystal structures of TolC and DSD, which form antiparallel 12-helical and six-helical bundles, respectively. The backbone geometries of the helical bundles of cytochrome bc(1), TolC, and DSD are well described using a simple D-n-symmetrical model with only eight adjustable parameters. This parameterization provides an excellent starting point for construction of minimal models of these proteins as well as the de novo design of proteins with novel functions. (C) 2001 Academic Press.
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