Journal
FEBS LETTERS
Volume 504, Issue 3, Pages 118-125Publisher
WILEY
DOI: 10.1016/S0014-5793(01)02702-8
Keywords
neuronal nicotinic acetylcholine receptor; ligand-gated channel; transmission; molecular structure
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Neuronal nicotinic acetylcholine receptors are a prototype of ligand-gated channels that mediate transmission in the central and peripheral nervous system. Structure-function studies performed at the amino acid level are now unraveling the determinant residues either for the properties of the ligand-binding domain or the ionic pore. In this work we review, in the light of the latest finding, the structure-function relationship of these receptors and their implication in neurological diseases. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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