Journal
ANALYST
Volume 140, Issue 18, Pages 6226-6229Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5an00945f
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Funding
- National Basic Research Program of China (973 Program) [2011CB935800]
- National Science Foundation of China [21275140, 21405152]
- Science and Technology Development Plan of Jilin Province [20130101126JC]
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The epithelial cell adhesion molecule (EpCAM) is a tumor-specific antigen for malignancies of the epithelialis lineage. In this study the interaction between the DNA-based EpCAM aptamer (SYL3C) and EpCAM was explored using single molecular recognition force spectroscopy (SMFS). The capability of aptamer SYL3C to recognize the EpCAM protein and the kinetic parameters were investigated.
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