Journal
BRITISH JOURNAL OF DERMATOLOGY
Volume 145, Issue 3, Pages 385-405Publisher
WILEY
DOI: 10.1046/j.1365-2133.2001.04399.x
Keywords
alopecia areata; contact hypersensitivity; dinitrochlorobenzene; diphencyprone; diphenylcyclopropenone; squaric acid dibutyl ester; topical immunotherapy; viral warts
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Topical therapy using contact sensitizers has been practised since the 1960s to treat conditions associated with an altered immunological state. Dinitrochlorobenzene, squaric acid dibutyl ester and diphencyprone are most commonly employed in the therapy of alopecia areata and viral warts. Few dermatology departments in the U.K. provide such treatment. This systematic review discusses the various contact sensitizers used for topical immunotherapy, the methodology of treatment, factors influencing efficacy and likely adverse effects.
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