Journal
GENES & DEVELOPMENT
Volume 15, Issue 17, Pages 2203-2208Publisher
COLD SPRING HARBOR LAB PRESS
DOI: 10.1101/gad.913901
Keywords
gamma irradiation; glucose tolerance; seminiferous tubular atrophy; thymocytes; mouse embryo fibroblasts
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Funding
- NCI NIH HHS [R01 CA090764, CA 90764] Funding Source: Medline
- NIA NIH HHS [R01 AG016927, AG 16927] Funding Source: Medline
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The serine/threonine kinase Akt has been implicated in the control of cell survival and metabolism. Here we report the disruption of the most ubiquitously expressed member of the akt family of genes, akt1, in the mouse. Akt1(-/-) mice are viable but smaller when compared to wild-type littermates. In addition, the life span of Akt1(-/-) mice, upon exposure to genotoxic stress, is shorter. However, Akt1(-/-) mice do not display a diabetic phenotype. Increased spontaneous apoptosis in testes, and attenuation of spermatogenesis is observed in Akt1(-/-) male mice. Increased spontaneous apoptosis is also observed in the thymi of Akt1(-/-) mice, and Akt1(-/-)thymocytes are more sensitive to apoptosis induced by gamma -irradiation and dexamethasone. Finally, Akt1(-/-)mouse embryo fibroblasts (MEFs) are mote susceptible to apoptosis induced by TNF, anti-Fas, UV irradiation, and serum withdrawal.
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