Journal
BEHAVIOURAL PHARMACOLOGY
Volume 21, Issue 8, Pages 677-689Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FBP.0b013e328340d630
Keywords
antidepressant; depression; formal models; hippocampus; hypothalamus-pituitary-adrenal axis
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Research in the field of depression and antidepressants is hampered by the lack of relevant endpoints. The two most promising targets in this area are hypothalamus-pituitary-adrenal axis dysfunction and defects in hippocampal function. However, there is no available model aimed at providing a relevant description of the relationship of these two endpoints and of their relevance for major depression. Formal models have been used to model biological functions, but few applications have been developed in the field of biological psychiatry and psychopharmacology. Here, we use formal models to integrate the hippocampal and the hypothalamus-pituitary-adrenal dysfunctions in relationship to major depression and antidepressant action. Even if our proposal is an oversimplification, this model generates predictions for the discovery of new pharmacological targets that might be helpful in designing treatments for the future. Behavioural Pharmacology 21:677-689 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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