Journal
BEHAVIOURAL PHARMACOLOGY
Volume 21, Issue 3, Pages 246-249Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FBP.0b013e32833a5b9d
Keywords
ABT-418; acetylcholine; learning; memory; mouse; nicotinic acetylcholine receptors; nicotine
Funding
- National Instutite on Drug Abuse [DA017949]
- NIDA [DA07237, DA024787-01A1S1]
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Activation of nicotinic acetylcholine receptors (nAChRs) is known to modulate various forms of learning and memory, including contextual fear conditioning. Although numerous studies have shown that high-affinity beta 2-containing nAChRs are necessary for the nicotine-induced enhancement of contextual fear conditioning, it is unknown whether other high-affinity nAChR agonists are capable of enhancing this learning. To examine this issue, ABT-418, a high-affinity nAChR agonist with greater selectivity for high-affinity receptors than nicotine, was administered before acquisition and/or recall of contextual fear memories. ABT-418 enhanced acquisition of contextual fear memories in a dose-dependent manner. Behavioural Pharmacology 21: 246-249 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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