Journal
BEHAVIOURAL PHARMACOLOGY
Volume 21, Issue 5-6, Pages 409-419Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FBP.0b013e32833c20c0
Keywords
chromatin; epigenetic; histone deacetylases; learning and memory; synaptic plasticity
Funding
- National Institute of Mental Health [MH081060]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH081060] Funding Source: NIH RePORTER
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Histone deacetylases (HDACs) are a family of enzymes that alter gene expression patterns by modifying chromatin architecture. There are 11 mammalian HDACs that are classified by homology into four subfamilies, all with distinct expression patterns in the brain. Through the use of pharmacological HDAC inhibitors, and more recently HDAC knockout mice, the role of these enzymes in the central nervous system are starting to be elucidated. We will discuss the latest findings on the specific or redundant roles of individual HDACs in the brain as well as the impact of HDAC function on complex behavior, with a focus on learning, memory formation, and affective behavior. Potential HDAC-mediated cellular mechanisms underlying those behaviors are discussed. Behavioural Pharmacology 21:409-419 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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