Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 2, Issue 9, Pages 688-698Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/35089575
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Over the past 100 years, the centrosome has risen in status from an enigmatic organelle, located at the focus of microtubules, to a key player in cell-cycle progression and cellular control. A growing body of evidence indicates that centrosomes might not be essential for spindle assembly, whereas recent data indicate that they might be important for initiating S phase and completing cytokinesis. Molecules that regulate centrosome duplication have beer identified, and the expanding list of intriguing centrosome-anchored activities, the functions of which have yet to be determined, promises continued discovery.
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