Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 268, Issue -, Pages 88-93Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2014.03.046
Keywords
Fingolimod; Alzheimer's disease; Amyloid beta; Brain-derived neurotrophic factor
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Funding
- japan Society for the Promotion of Science [25460094]
- Takeda Science Foundation
- Advanced Research for Medical Products Mining Program of the National Institute of Biomedical Innovation (NIBIO)
- Grants-in-Aid for Scientific Research [25460094] Funding Source: KAKEN
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Alzheimer's disease is a progressive neurodegenerative disorder. Amyloid beta, a neurotoxic protein, causes disruption of hippocampal synaptic plasticity, and induces cognitive impairment in Alzheimer's disease. We previously. revealed that fingolimod, a new oral immunosuppressant used to treat multiple sclerosis, ameliorates oligomeric amyloid beta-induced neuronal damage via up-regulation of neuronal brain-derived neurotrophic factor (BDNF). Here, we showed that oral administration of fingolimod ameliorated the impairment in object recognition memory and associative learning in mice injected with amyloid beta. This effect was associated with restoration of normal BDNF expression levels in the cerebral cortices and hippocampi, suggesting that neuroprotection was mediated by up-regulation of neuronal BDNF levels. Therefore, fingolimod may provide therapeutic effects in patients with Alzheimer's disease. (C) 2014 Elsevier B.V. All rights reserved.
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