Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 250, Issue -, Pages 91-101Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2013.04.037
Keywords
mPFC; Prefrontal cortex; ACC; Anterior cingulate cortex; Attention; Set-shifting
Categories
Funding
- NIDA [R01DA031695]
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Impaired attentional set-shifting and inflexible decision-making are problems frequently observed during normal aging and in several psychiatric disorders. To understand the neuropathophysiology of underlying inflexible behavior, animal models of attentional set-shifting have been developed to mimic tasks such as the Wisconsin Card Sorting Task (WCST), which tap into a number of cognitive functions including stimulus-response encoding, working memory, attention, error detection, and conflict resolution. Here, we review many of these tasks in several different species and speculate on how prefrontal cortex and anterior cingulate cortex might contribute to normal performance during set-shifting. (C) 2013 Elsevier B.V. All rights reserved.
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