Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 58, Issue 10, Pages 1491-1521Publisher
SPRINGER BASEL AG
DOI: 10.1007/PL00000791
Keywords
transthyretin; throxine; retinol; vitamin A; amyloid; structure
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Transthyretin (formerly called prealbumin) plays important physiological roles as a transporter of thyroxine and retinol-binding protein. X-ray structural studies have provided information on the active conformation of the protein and the site of binding of both ligands. Transthyretin is also one of the precursor proteins commonly found in amyloid deposits. Both wild-type and single-amino-acid-substituted variants have been identified in amyloid deposits, the variants being more amyloidogenic. Sequencing of the gene and the resulting production of a transgenic mouse model have resulted in progress toward solving the mechanism of amyloid formation and detecting the variant gene in individuals at risk.
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