Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 227, Issue 1, Pages 287-290Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2011.10.036
Keywords
Elevated plus maze; Estradiol; Forced swim test; Raloxifene; Tamoxifen
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Funding
- Plan Nacional de Investigacion, Spain [BFU2008-02950-C03-01/02]
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Estradiol has antidepressive and anxiolytic actions. However, its therapeutic use is limited by its peripheral effects. Selective estrogen receptor modulators may represent an alternative to estradiol for the treatment of depressive symptoms. Here we report that tamoxifen and raloxifene decrease immobility time in the forced swim test and increases the time spent in open arms in the elevated plus maze in ovariectomized mice submitted to chronic unpredictable stress. (C) 2011 Elsevier B.V. All rights reserved.
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