Journal
BIOSENSORS & BIOELECTRONICS
Volume 16, Issue 7-8, Pages 565-570Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/S0956-5663(01)00170-1
Keywords
field effect transistors; extracellular recording; dissociated cardiac myocytes; pharmacological biosensor
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An extracellular recording system has been designed for the detection of electrical cell signals using p-channel or n-channel field-effect transistor (FET) arrays with non-metallized gates. Signals from rat heart muscle cell were recorded by these devices and the results described on the basis of an equivalent circuit. This technique is sensitive enough to detect minute changes of the extracellular membrane voltage and has potential applications in drug screening. We show that known cardiac stimulants (isoproterenol, norepinephrine) and relaxants (verapamil, carbamylcholine) have characteristic effects on the heart cells in terms of the changes of beat frequencies in the absence or presence of corresponding agents. (C) 2001 Elsevier Science B.V. All rights reserved.
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