Journal
PARKINSONISM & RELATED DISORDERS
Volume 8, Issue 1, Pages 1-5Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1353-8020(00)00084-5
Keywords
dopa-responsive dystonia; levodopa; dyskinesia; dopamine turnover
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We report the long-term response to levodopa in 20 patients with dopa-responsive dystonia (DRD). We found an inverse correlation between the daily dose of levodopa and duration of treatment (r = -0.59, P < 0.01). Mild dyskinesias were present in 20% of our patients. Dyskinetic patients were on a higher dose of levodopa than non-dyskinetics. Dyskinesias responded to a reduction in levodopa, with no deterioration in motor function. We propose that the dopamine turnover might decrease with time, which would lead to a decrease in the requirement for levodopa and the occurrence of dyskinesias late in the course of DRD. (C) 2001 Elsevier Science Ltd. All rights reserved.
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