Journal
JOURNAL OF BACTERIOLOGY
Volume 183, Issue 17, Pages 5209-5212Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.183.17.5209-5212.2001
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Formation of DNA adducts following conversion of dichloromethane by bacterial dichloromethane dehalogenase/glutathione S-transferase was demonstrated. Adducts included dichloromethane carbon and glutathione sulfur atoms. A reaction with DNA occurred preferentially at guanine bases. Increased DNA degradation in a polA mutant of Methylobacterium dichloromethanicum DM4 grown with dichloromethane confirmed the genotoxicity associated with dichloromethane degradation, suggesting an important role of DNA repair in the metabolism of halogenated, DNA-alkylating compounds by bacteria.
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