Journal
DIAGNOSTIC MOLECULAR PATHOLOGY
Volume 10, Issue 3, Pages 139-152Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00019606-200109000-00001
Keywords
breast carcinoma; Her-2/neu; c-erb-B2; herceptin; trastuzumab
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Breast cancer is the most common malignancy in women in the United States in the year 2000. The proto-oncogene Her-2/neu (c-erb-B2) has become an increasingly important prognostic and predictive factor in breast cancer. Overexpression/amplification of the Her-2/neu has been associated with a worse outcome in patients with breast cancer. Herceptin, a humanized murine monoclonal antibody directed against the extracellular domain of the Her-2/neu protein, is being used to treat breast cancer that overexpresses Her-2/neu. The status of Her-2/neu in the tumor has become a critical factor in the management strategy of a breast cancer patient. The objective of this article is to provide a comprehensive review of all aspects of Her-2/neu in breast cancer, including biology, prognostic and predictive value, targeted Herceptin therapy, and the laboratory testing of Her-2/neu.
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