Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 233, Issue 2, Pages 293-297Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2012.05.010
Keywords
Cycloheximide; Protein synthesis; Memory enhancement; Long-term memory; Consolidation; Inhibitory avoidance
Categories
Funding
- NIDA [R21 DA024129]
- NIA [R01 AG07648]
- NSF [IOS 08-43175, 10-52464]
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This experiment examined the effects on memory of interactions of cycloheximide dose and training foot shock intensity. Mice received injections of cycloheximide (120 mg/kg, s.c.) or saline 30 min prior to inhibitory avoidance training with shock intensities of 100, 150, 250 or 300 mu A (1 s duration). Memory was tested 48 h later. The saline control mice showed increasing memory latencies as a function of shock intensity. The ability of cycloheximide to impair memory increased as the training shock intensity increased. In a second experiment, mice were trained with a 200 mu A (1 s duration) shock and received injections of saline or cycloheximide at one of several doses (30, 60 or 120 mg/kg). Under these training conditions, cycloheximide enhanced memory in an inverted-U dose-response manner. These findings are consistent with prior findings suggesting that protein synthesis inhibitors act on memory by altering modulators of memory formation as a secondary consequence of the inhibition of protein synthesis rather than by interfering with training-initiated synthesis of proteins required for memory formation. (c) 2012 Elsevier B.V. All rights reserved.
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