Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 216, Issue 1, Pages 419-423Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2010.08.034
Keywords
Associative learning; Memory maintenance; Addiction; Rat; Psychostimulant; GABA(B) receptor; GS39783; CGP7930; Drug-seeking; Reward
Categories
Funding
- USPHSGs [DA015760, DA021475, DA023306]
- NATIONAL INSTITUTE ON DRUG ABUSE [F31DA023306, F31DA021475, R01DA015760] Funding Source: NIH RePORTER
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Little is known about the role of GABA(B) receptors (GABA(B)Rs) in the maintenance of memories associated with using abused substances. We have embarked on a series of studies designed to determine if enhancing the efficacy of GABA-occupied GABA(B)Rs with positive allosteric modulators (PAMs) can negate previously established conditioned place preference (CPP) induced by methamphetamine. In the current study, we evaluated the effects of acute administration of GABA(B)R PAMs, GS39783 and CGP7930. We determined that post-conditioning treatments with these PAMs, administered in the home cage, blocked the subsequent expression of methamphetamine-induced CPP. These data indicate that selectively augmenting GABA-occupied GABA(B)R signaling is sufficient to reduce memory maintenance and/or the salience of contextual cues previously associated with methamphetamine. (C) 2010 Elsevier B.V. All rights reserved.
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