Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 216, Issue 1, Pages 463-465Publisher
ELSEVIER
DOI: 10.1016/j.bbr.2010.07.034
Keywords
Lateral habenula; Depression; Learned helplessness; Treatment resistance; LHb; cLH
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Identifying new treatment approaches for treatment resistant depression (TRD) is an important topic for translational psychiatry. Functional inhibition of the lateral habenula (LHb) has recently been claimed to offer such an option for TRD. Rats which are bred for high susceptibility to develop learned helplessness provide a genetic model for TRD. We used the gamma-aminobutyric acid agonist muscimol to inhibit the LHb in Sprague-Dawley rats with congenital learned helplessness (cLH). Stereotactic pharmacological inhibition of the LHb exerted antidepressive effects in treatment resistant cLH rats. (C) 2010 Elsevier B.V. All rights reserved.
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