Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 221, Issue 1, Pages 329-332Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2011.03.033
Keywords
Sodium butyrate; Histone deacetylase; Recognition memory; Epigenetics; Memory consolidation
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Funding
- National Council for Scientific and Technological Development (CNPq) [303703/2009-1, 305905/2009-0]
- National Institute of Mental Health (NIMH) [R01MH081004]
- National Institute for Translational Medicine (INCT-TM, Brazil)
- South American Office for Anticancer Drug Development
- CNPq
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Here we show that a systemic injection of the histone deacetylase inhibitor (HDACi) sodium butyrate (NaB) ameliorated an aging-associated deficit in object recognition memory in rats when the injection was given immediately, but not 6 h after training. NaB had no effect in younger rats with normal memory retention. The results indicate that HDACis can ameliorate aging-related memory impairments by influencing the early consolidation phase of memory formation. (C) 2011 Elsevier B.V. All rights reserved.
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