Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 222, Issue 1, Pages 265-269Publisher
ELSEVIER
DOI: 10.1016/j.bbr.2011.02.043
Keywords
TIP39 signaling; Fear memory; Anxiety; Depression-like behavior
Categories
Funding
- NIH, National Institute of Mental Health
Ask authors/readers for more resources
Exaggerated recall for fear-provoking events leads to abnormal behaviors. We hypothesized that tuberoinfundibular-peptide-of-39-residues (TIP39) modulates fear memory by limiting long-term consequences of aversive experiences. We now show that mice lacking TIP39 signaling display enhanced fear-recall, anxiety and depression-like behavior 2 weeks after a traumatic event. We suggest that TIP39 modulates long-term fear recall and that mice lacking TIP39 or its receptor are tools for investigating fear-related psychopathologies. Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available