Journal
NEUROCHEMICAL RESEARCH
Volume 26, Issue 8-9, Pages 925-932Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1023/A:1012380416876
Keywords
ionotropic glutamate receptors; NMDA receptor; AMPA receptor; adenosine A(2A) receptor; phosphorylation
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Glutamate is the major excitatory neurotransmitter in the brain. It acts at ligand-gated cationic channels (NMDA, AMPA and kainate receptors) and at G protein-coupled metabotropic glutamate receptors as well. The glutamatergic transmission is suggested to be involved in development, learning and memory. Its dysfunction can be detected in epilepsy, stroke, neurodegenerative disorders and drug abuse. This paper summarizes the present knowledge on the modulation of glutamate-gated ion channels in the central nervous system by phosphorylation. An inhibitory interaction between adenosine A(2A) receptors and NMDA receptors in the neostriatum is described as an example, mediated by the phospholipase C/inositol trisphosphate/calmodulin and calmodulin kinase II pathway.
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