Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 217, Issue 2, Pages 309-314Publisher
ELSEVIER
DOI: 10.1016/j.bbr.2010.10.031
Keywords
Social modulation of avoidance; Medial prefrontal cortex; Lesions; Rats
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan [0907565]
- Grants-in-Aid for Scientific Research [23659123] Funding Source: KAKEN
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Our previous study showed that social interactions induce inhibitory and facilitatory modulations of avoidance behavior under both safe and dangerous situations in rats. To understand the neural mechanisms for these phenomena, we investigated the effects of bilateral lesions of the medial prefrontal cortex (mPFC) on the social modulation of avoidance behavior. We found that the lesions did not impair but actually augmented both social inhibition and facilitation of avoidance. These results suggest that the mPFC in rodents plays a suppressive role in the social modulation of avoidance. (C) 2010 Elsevier B.V. All rights reserved.
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