The effects of age on lipopolysaccharide-induced cognitive deficits and interleukin-1β expression

An acute LPS challenge immediately following day 1 of shuttlebox training triggered exacerbated central IL-1 beta production and disrupted memory consolidation and/or further acquisition of the task in 18-month-old mice, compared to 4-month-old controls. These deficits cannot be attributed to alterations in sickness behavior. The findings suggest that age and immune activation combine to impair learning and memory consolidation processes, and that increased central IL-1 beta production may play a role. (C) 2010 Published by Elsevier B.V.