Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 222, Issue 2, Pages 390-393Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2011.03.064
Keywords
Cue; Eticlopride; Food seeking; Reinstatement; Relapse; SCH-23390
Categories
Funding
- Pennsylvania State System of Higher Education
- Bloomsburg University Foundation, Inc.
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We used a rat reinstatement model to test the involvement of dopamine D-1- and D-2-like receptors in discrete cue-induced reinstatement of food seeking. At a dose that did not alter responding during food self-administration, the D-1-like antagonist SCH-23390 blocked reinstatement of food seeking, while the D-2-like antagonist eticlopride significantly increased reinstatement responding. Thus, these results establish opposing roles for D-1- and D-2-like receptors in discrete cue-induced relapse to food seeking. (C) 2011 Elsevier B.V. All rights reserved.
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