Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 218, Issue 2, Pages 357-362Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2010.12.029
Keywords
Corticotropin-releasing factor; Stress; Transgenic mice; Habituation; Social recognition; Social discrimination; Memory
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We examined juvenile social recognition and discrimination in mice with early post-natal onset, transgenic CRF over-expression (CRF-OE) and in their wild-type littermates (WT). CRF-OE mice showed enhanced social investigation during the first encounter, normal short-term and facilitated long-term social recognition memory, compared to WT. These results suggest that chronically elevated brain CRF tone may contribute in better remembering ethologically relevant and emotionally salient stimuli, such as social interaction. (C) 2010 Elsevier B.V. All rights reserved.
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