Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 210, Issue 2, Pages 280-283Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2010.02.038
Keywords
Morris water maze; Memory; Neurotensin; Central nucleus of amygdala
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Funding
- Hungarian Academy of Sciences
- Pecs University Medical School
- NKTH-OTKA [K 68431]
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Neurotensin (NT) acts as a neurotransmitter and/or neuromodulator and plays a role in learning and reward related processes. The central nucleus of amygdala (CeA) participates in the regulation of memory and learning mechanisms. In Morris water maze test, rats were microinjected with NT or neurotensin receptor-1 (NTS1) antagonist SR 48692 (ANT). NT significantly reduced the escape latency. Effect of NT was blocked by ANT pretreatment. Our results show that in the rat CeA NT facilitates spatial learning. We clarified that NTS1s are involved in this action. (C) 2010 Elsevier B.V. All rights reserved.
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