Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 209, Issue 2, Pages 234-240Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2010.01.049
Keywords
Alpha-synuclein; Anxiety; Mice; Open field; Elevated plus maze; Light-dark box
Categories
Funding
- European Community [LSHM-CT-2007-037286]
- The Wellcome Trust
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Alpha-synuclein is implicated in the pathology of Parkinson disease (PD) and is involved in synaptic function, particularly in presynaptic events in dopamine (DA) synapses. Recently, a role for alpha-synuclein in reward and addiction, especially in alcoholism, has been reported. Since PD and alcohol dependence present a strong comorbidity with anxiety disorders, a role for alpha-synuclein in anxiety has been proposed. The aim of the present investigation was to study the involvement of alpha-synuclein in anxiety by testing alpha-synuclein knock out and wild type mice in three different emotionality tests: the open field, the elevated plus maze and the light-dark box. Alpha-synuclein knock out mice and wild type controls displayed consistently similar emotionality profiles in all the tests, suggesting a lack of involvement of alpha-synuclein in unconditioned anxiety in mice. (C) 2010 Elsevier B.V. All rights reserved.
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