Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 211, Issue 2, Pages 215-219Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2010.03.042
Keywords
Periaqueductal gray; PAG; Pain; fMRI; Resting state; Functional connectivity
Categories
Funding
- NIH (NCCAM) [K01 AT003883, R21AT004497]
- National Center for Research Resources (NCRR) [M01-RR-01066, UL1 RR025758-01, P41RR14075]
- MIND Institute
Ask authors/readers for more resources
The periaqueductal gray (PAG) is known to play a crucial role in pain modulation and has shown a strong interaction with anterior cingulate cortex in previous functional imaging studies. We investigated the intrinsic functional connectivity of PAG using resting fMRI data from 100 subjects. The results showed that PAG is functionally connected to ACC (rostral and pregenual ACC) and also rostral ventromedial medulla (RVM), forming a core ACC-PAG-RVM network for pain modulation even no pain stimulus is applied. The comparison between genders showed that for the contrast of female minus male, significant difference was observed at mid-cingulate cortex; for the contrast of male minus female, significant differences were observed at left medial orbital prefrontal cortex, and uncus; right insula/operculum and prefrontal cortex. We believe eluciation of this intrinsic PAG network duing the resting state will enhance our physiological and pathological understandings of the development and maintenance of chronic pain states. (C) 2010 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available