Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 208, Issue 1, Pages 278-281Publisher
ELSEVIER
DOI: 10.1016/j.bbr.2009.11.036
Keywords
Psychostimulant; CRF2 receptor; ASV-30; Elevated plus maze; Serotonin; Addiction
Categories
Funding
- NIH [CONE P20 RR015567, R01 DA019921]
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Withdrawal from psychostimulants increases anxiety states, and amphetamine-treated rats show increased CRF2 receptors in the serotonergic cell body region, the dorsal raphe nucleus (dRN). In the current study, amphetamine (2.5 mg/kg, i.p., 14 days) pre-treated rats spent less time in open arms of the elevated plus maze compared saline pre-treated rats at both 24 h or 2 weeks of withdrawal, and CRF2 receptor antagonism (ASV-30; 2 mu g/0.5 mu l) within the dRN reversed the effects of amphetamine withdrawal on anxiety-like behavior. Overall, results suggest that CRF2 receptor antagonism may be a novel pharmacological target for anxiety states during drug withdrawal. (C) 2009 Elsevier B.V. All rights reserved.
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